Patient guide

Why is weight loss so hard? The role of hormones

Difficulty losing weight is not simply a lack of willpower. The body actively defends its weight.

The body pushes back

When you lose weight, hunger hormones change: leptin falls and ghrelin rises, so you feel hungrier, and the body burns slightly less energy than expected. This is why regaining weight is so common, and why a long-term plan matters more than a quick diet.

What else plays a part

  • Genes, which strongly influence body weight
  • Short or poor sleep, shift work and stress
  • Medicines such as steroids, insulin, some diabetes tablets, some antidepressants, antipsychotics and anti-epileptic drugs
  • Life stages such as pregnancy and menopause

Is it my hormones?

Most people with obesity do not have a single hormonal cause, but some conditions do add weight and are worth checking for:

  • An underactive thyroid, which usually causes modest weight gain along with tiredness and feeling cold
  • PCOS, with irregular periods, acne or excess hair
  • Cushing syndrome (too much cortisol), which is rare: purple stretch marks, easy bruising, muscle weakness and a round face
  • Insulin resistance, often with a dark velvety skin patch on the neck

What works

  • A realistic goal: losing 5% to 10% of body weight improves blood sugar, blood pressure and fatty liver
  • Meals built around vegetables, protein and fibre, with fewer sugary drinks and refined snacks
  • Regular activity, including strength training
  • Better sleep
  • Medically supervised treatment: anti-obesity medicines for selected people, and bariatric surgery for those who meet criteria (thresholds are lower for Asian populations)

When to see a specialist

Consider an endocrinology opinion if you are gaining weight despite real effort, have diabetes, PCOS or fatty liver, take medicines that may add weight, or have features of a hormone problem.

This guide is general information and is not a substitute for a consultation.

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